Anastrozole(Arimidex)

Description:

1. Arimidex is the trade name used by the pharmaceutical company AstraZeneca, for a drug called Anastrozole. Many bodybuilders like to refer to it as just ‘adex’ for short. Approved in the US for use in 1995, it is a non-steroidal aromatase inhibiting drug (acronym AI) and is approved for treatment of breast cancer after surgery and for metastasis in women. Since breast cancer can be heightened by the increase in estrogen, arimidex is used to inhibit the synthesis of estrogen.

2. Arimidex (Anastrozol) is one of the most welcome PCT products.As an aromatase inhibitor, Arimidex’s mechanism of action – blocking conversion of aromatizable steroids to estrogen – is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or tamoxifen (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others. During a cycle, if using Arimidex, there is generally no need to use Clomid as well, but (as mentioned in the section on Clomid) there may still be benefits to doing so.

3. Anastrozole (INN) ( Arimidex ) is a non-steroidal aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer can be increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites.Anastrozole works by inhibiting the synthesis of estrogen. This medication is used to treat breast cancer in women who have gone through “the change of life” (menopause). Anastrozole works by lowering estrogen hormone levels to help shrink tumors and slow their growth.

Application

Although Arimidex does increase testosterone levels slightly in the body, it is more often used in conjunction with other steroids to lower estrogen in the body. Many anabolic steroids will convert, or aromatize, in the body into estrogen, which causes many of the unwanted side effects like bloating and acne. Arimidex is one of the best compounds to lower the aromatizing effect of steroids

For the steroid using male athlete, Arimidex shows great potential. There are some concerns with using an aromatase inhibitor such as this during prolonged steroid treatment however. While it will effectively reduce estrogenic side effects, it will also block the beneficial properties of estrogen from becoming apparent (namely its effect on cholesterol values). Studies have clearly shown that when an aromatase inhibitor is used in conjunction with a steroid such as testosterone, suppression of HDL (good) cholesterol becomes much more pronounced. Apparently estrogen plays a role in minimizing the negative impact of steroid use. Since the estrogen receptor antagonist Nolvadex is shown not to display an anti-estrogenic effect on cholesterol values, it is certainly the preferred from of estrogen maintenance for those concerned with cardiovascular health.

How anastrozole works:

Hormones are substances produced naturally in the body. They act as chemical messengers and help control the activity of cells and organs. Hormonal therapies interfere with the way hormones are made or how they work in the body.

Many breast cancers rely on the hormone oestrogen to grow. This type of breast cancer is called oestrogen receptor-positive (ER positive) breast cancer.

After the menopause, oestrogen is no longer made in the ovaries. Instead, it’s made in the fatty tissues of the body. This happens when an enzyme called aromatase changes other hormones into oestrogen. Anastrozole is a drug called an aromatase inhibitor. It blocks this process and reduces the amount of oestrogen in the body.

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