Letrozol/ Femara Profil
| Product name | Letrozol |
| Other name | Femara |
| CAS register number | 112809-51-5 |
| Melting Point | 116-118º C |
| Molecular formula | C17H11N5 |
| Molecular weight | 285.3 |
| Assay | 98% |
| Appearance | White crystalline powder |
| Usage | An aromatase inhibitor. |
COA
| Tests | Specifications | Results |
| Appearance | White or off-white crystaline powder | White Crystalline powder |
| Solubility | Soluble in Chloroform; Soluble in ethanol when heated | Conform |
| ldentification | (1)Maximum absorption in wavelength of 240 nm Minimum absorption in wavelength of 215 nm | Conform Conform |
| (2)Infrared spectrum should be in accordance the dominant peak of contrast | In accordance with the dominant peak of contrast | |
| Melting points | 182ºC-184ºC | 182ºC |
| Related substances | ≤0.5% | 0.3% |
| Single impurity | ≤0.3% | 0.2% |
| Loss on drying | ≤1.0% | 0.8% |
| [Assay]C17H11N5 (On anhydrous basis) | ≥98.0% | 99.2% |
| Conclusion | Conforms Specifications of Enterprise Standard. |
Letrozole(Femara)
Description:
Letrozol is an anti-estrogen of the Aromatase Inhibitor family and is one of the most potent and powerfully effective of all AI’s.It was first developed in an effort to combat breast cancer in post-menopausal women.Letrozol is an oral aromatase inhibitor which is a non-steroidal drug.
Letrozol treats hormonally responsive breast cancer after the surgery in females past menopause. It belongs to the class of drugs known as Aromatase inhibitors and Hormones antineoplastics.It acts by decreasing the quantity of estrogen synthesized in the body.
And it is one of the most commonly used anti-estrogens among steroiders during steroid use to combat possible estrogenic related side effects. It is so effective as an anti-estrogen in this regard many anabolic steroids have effectively reversed gynecomastia symptoms withLetrozol.
Applications:
Femara (letrozole) is a type II (non-steroidal) third generation aromatase inhibitor. Clinically it is used to treat postmenopausal women with either estrogen receptor positive or estrogen receptor unknown breast cancer.
In women with breast cancer, it has been shown to reduce estrogen levels by 98% or more . However, it’s use and benefits are not limited to eliminating estrogen in women.
For pre-contest bodybuilders, Letrozole is almost a necessity to eliminate water retention and achieve the ripped look necessary to compete in today’s bodybuilding world. However, in my experience, it is only necessary to be used for the last 4-6 weeks, to eliminate excess estrogen and water retention. After using Letrozole I recommend staying away from any estrogen suppression for at least a month to try to normalize the body.
How Femara works
Femara lowers the levels of the female sex hormone oestrogen in the body. Oestrogen stimulates some breast cancers to grow. These breast cancers are called hormone sensitive or hormone receptor positive. Femara can stop or slow the growth of these cancers. It can also reduce the chance of a breast cancer coming back after surgery.
Femara only works in women who have had their menopause. It is a type of drug called an aromatase inhibitor. After the menopause, women don’t produce oestrogen from their ovaries. But they still produce a small amount by using an enzyme called aromatase which turns other sex hormones called androgens into oestrogen. This change happens mainly in fatty tissue, muscle and the skin. Aromatase inhibitors block aromatase so that it can’t change the androgen into oestrogen.
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